The shock wave has a number of effects on the tissue. In the process of calcification, calcium deposits are building up in muscles and tendons. The overpressure phase of the shock wave is disrupting and subsequently absorbing them via the vascular and lymphatic system. Therapy changes the blood supply to the area, local hyperemia develops and the process of neovascularization (formation of new blood vessels) begins. Mechanical energy, applied vertically to the muscle fibers direction, relaxes them and the actin-myosin bonds are released. It is proven that shock wave supports stem cell differentiation and is beneficial for the quality of bone and fibrous structures. The analgesic effect of the shock wave therapy is significant and is based on reducing the sensitivity of the fibers carrying informations related to pain, influencing inhibitory interneurons and other neurophysiological and biochemical processes such as reducing the release of the P substance which can last up to 6 weeks after application – thus providing long-term pain relief *.